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What Is Swelling? · Some chemotherapy drugs can cause fluid retention in the body. This form of cancer swelling is most noticeable in the feet, ankles, hands. What Causes Edema? · If the right side of the heart is weak, pressure will build in the peripheral tissues in the body (hands, ankles, feet, legs). This is. Edema is buildup of fluid in the leg, especially feet, ankles, and calves. Its origins are often the result of both lymphatic dysfunction and vascular disease.

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Problems with the veins in the legs (varicose veins) and changes in hormones can also cause swelling. Sometimes the swelling in the ankles and feet is caused by. Leg Swelling in a Single Leg · Infection in the foot or leg · Muscle strain or tear in the affected leg · Blockage of the leg's lymphatic system · A Baker's cyst . What Is Swelling? · Some chemotherapy drugs can cause fluid retention in the body. This form of cancer swelling is most noticeable in the feet, ankles, hands.

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Causes may include venous insufficiency, heart failure, kidney problems, low protein levels, liver problems, deep vein thrombosis, infections, angioedema. Natural hormonal changes. Fluctuating levels of estrogen and progesterone can cause reduced circulation in the legs, resulting in swelling. · Blood clot in the. Edema (or swelling) of the lower limbs is common in older adults. The most common cause (about 70%) of leg edema is due to Chronic Venous Insufficiency (CVI).